Molecular Formula | C6H6FN3O |
Molar Mass | 155.13 |
Boling Point | 396.6℃ |
Storage Condition | 2-8℃ |
Application | 2-fluorisoniazid and p-aminosalicylic acid isoniazid have become its alternative drugs. Most doctors still believe that 2-fluorisoniazid is an indispensable main drug for the treatment of tuberculosis. It is also a first-line anti-tuberculosis drug with rifampicin (rifampicin), ethambutol (ethambutol), streptomycin (sterptomycin) and pyrazinamide (pyrazinamide). |
preparation | add 1.62mol 2-fluoroisonicotinic acid, 1200g ethanol and 16.4g(0.162mol) triethylamine to a 2000ml three-mouth bottle, stir and cool to 0 ℃ ~ 5 ℃, slowly add 212g(1.78mol) thionyl chloride dropwise, and keep the temperature at 0 ℃ ~ 5 ℃ for 2 hours, then raise the temperature to 20 ℃ ~ 25 ℃ and keep the temperature for 20 hours. After the reaction is completed, concentrate under reduced pressure to obtain an oily substance. Add 119g(2.43mol) of hydrazine hydrate, raise the temperature to 70 ℃ ~ 75 ℃, keep the temperature for 10 hours, add diluent (350g of water), appropriately raise the temperature and dissolve it to obtain an aqueous solution of 2-fluorine isoniazid crude product. Add 10g of activated carbon and keep the temperature at 70 ℃ ~ 75 ℃ for half an hour, filtration, the filtrate is naturally cooled for 6 hours, then slowly cooled to 0 ℃, filtered and dried to obtain isoniazid finished product with 99.94% purity, single impurity less than 0.10%, impurity J is not detected, and the total yield of 2-fluorisoniazid is 86%. |